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教授

张效伟

教授,博士生导师(环境毒理学)
南京大学有毒化学品环境安全研究中心主任

南京大学环境学院“生态毒理和环境健康”研究团队负责人。博士毕业于美国密西根州立大学,先后入选教育部“新世纪优秀人才支持计划”, 国家自然科学基金“优秀青年科学基金”,江苏省“333高层次人才培养工程”,江苏省“双创人才引进计划”,和江苏省“杰出青年基金”等。目前主要主持承担“十二五”国家“863”计划化学品重大专项课题,国家重大科技水专项子课题和欧盟“FP7”环境领域解决方案项目子课题等科研计划。发表英文SCI论文70多篇,包括以一作或通讯作者在在国际权威学术刊物Environmental Science & Technology和Toxicological Science上发表论文近20篇,其h index 为18,同时是一项授权美国专利的第一发明人。由其参与设计研发的Steroidogenesis Assay 在2009年初被美国环保局官方和世界经济合作与发展组织(OECD)采纳为环境内分泌干扰物质筛选的标准方法,成为全球通用的标准。

教育背景

2004-2008 美国密歇根州立大学,动物学和环境毒理学(双学科博士)
2006-2007 美国密歇根州立大学,应用统计学(硕士)
2000-2003 香港城市大学,环境科学(硕士)
1996-2000 南京大学,环境科学与工程(本科)

工作经历

2010- 今 南京大学环境学院教授
2009-2010 加拿大萨斯喀彻温大学毒理学中心,项目科学家
2008-2009 加拿大萨斯喀彻温大学毒理学中心,博士后
2003-2004 美国密歇根州立大学,国家食品安全和毒理学研究中心,访问学者

研究领域

1.化学品分子毒理学,毒理基因组学和高通量筛选技术研究
2.环境基因组学与新型生物监测技术研究
3.化学品生态安全与环境风险研究

学术兼职

1.Environmental Toxicology & Chemistry, Editor (2013-2016)
2.Environmental Science Europe, Editor (2013-2016)
3.Bulletin of Environmental Contamination and Toxicology, Editor (2013-2014)
4.Chemosphere, Editor (2011-2012)
5.中国环境科学学会持久性有机污染物专业委员会青年委员(2012-- )

欢迎喜爱分子毒理学、基因组学、生物信息学、生态毒理学、化学品安全与风险管理的同学报考研究生。我们同时招收实验室技术员、博士后、访问学者、及专职科研岗位(研究员),有意者请联系zhangxw@nju.edu.cn
更多张效伟教授课题组信息,请登陆:http://hjxy.nju.edu.cn/zhangxw

主要科研项目

自2010年以来承担的国家及省级科研项目:
1、主持, 国家“863”计划课题,2013AA06A309, “典型沿江化工区风险甄别与控制综合示范” ,2013-2015
2、主持, 江苏省“杰出青年基金”研发基于DNA条形码的化学品污染生态监测和风险预…(SBK201310181),2013-2016
3、主持,国家自然科学基金委“优秀青年基金”项目,“化学品毒理基因组学”,2014-2016
4、参加,欧盟FP7课题 FP7-ENV-2013,603427-2, “Solutions for present and future emerging pollutants in land and water resources management”,2013-2018.
5、主持,“从芳烃受体的基因型研究卤代芳烃污染物的鸟类种间敏感性差异”,国家自然科学青年基金项目(#21007025),2011-2013.
6、主持,“新型环境生物监测技术的研发及应用示范”,江苏省科技支撑计划社会发展基金项目(#BE2011776),2011-2014。
7、主持,“自然保护区风险源头识辨与预警技术研究”,江苏省环保科研基金(#3011356),2011-2012.
8、主持,教育部2011年“新世纪人才计划“,2011-2013
9、子课题负责人,国家科技重大 “水体污染控制与治理” 专项课题“太湖流域(江苏)水生态监控系统建设与业务化运行示范”(2012ZX07506003),2012-2015。
10、主持,“饮用水源水遗传毒性物质和内分泌干扰物质预警技术和风险评估方法研究”,江苏省环境监测科研基金项目(#1012),2010-2012。
11、主持,教育部2012年度高等学校博士学科点专项科研基金课题(博导类)。“新型替代阻燃剂化合物的生态毒理基因组学研究”(20120091110034),2012-2015。
12、主持, 国家外专局2012年度“高端外国专家项目”(文教类)。项目编号GDW20123200120,(2012.7.1-2013年6月30日)
13、子课题负责人,国家环保部公益课题,“高关注新型POPs 监测方法与POPs 监测新技术研发”,2012-2015。
14、参加,“基于水生态功能分区的水质标准管理与示范”,国家重大水专项课题“太湖流域水生态功能分区与标准管理工程建设课题”,2012-2015.

自从2006年以来在国外参加的主要科研项目:

1、“计算毒理学和内分泌干扰物---系统生物学在环境危险物质鉴定和风险评估(Computational Toxicology and Endocrine Disrupters: Use of Systems Biology in Hazard Identification and Risk Assessment),美国环境保护署STAR 计划(USA Environment Protection Agency, STAR Program),$1,588.5000美元,2007-2009
2、“创建加拿大新型的毒理学研发和化学物质毒性测试工业(Establishment of a Novel Toxicology Research, Development, and Chemical Testing Industry, Canada)”,加拿大政府西部经济发展基金(Western Economic Diversification Foundation)。$1,770,000 加元;2008-2011
3、“对加拿大西部油砂工业处理废水的修复及其环境影响的预测和监测(Remediation of Oil Sands Process Water and Predicting and Monitoring of Environmental Effects)”,加拿大国家科学和工程研究基金会(Natural Science Engineering Research Council of Canada (NSERC)),$800,000加,2008-2011
4、“评估泰克明科金属公司排放的工业废水对处于生命早期的鲟鱼的生态毒理学影响(Toxicological Assessment of White Sturgeon (Acipenser transmontana) Early Life Stages Exposed to Liquid Effluents of the Teckcominco Metals Ltd. Trail Facility)”,加拿大矿业公司(泰克明科公司)(Teckcominko, Inc.),$1,900,000加元,2007- 2010
5、“评估和建立海洋水质基准(香港行政特区)(Review and Development of Marine Water Quality Objectives)”,香港行政特区环境保护署(Environmental Protection Department, Hong Kong SAR),8,700,000 HKD,2008-2010

主要荣誉及获奖

1、2013年国家自然科学基金委“优秀青年基金”获得者
2、2013年江苏省“杰出青年基金”获得者
3、2013年江苏省“双创计划”入选者
4、教育部2011年“新世纪优秀人才支持计划”入选者
5、江苏省2011年“333高层次人才培养工程” 中青年科学技术带头人
6、第27届SETAC北美年会上获得爱思唯尔/SETAC优秀学生论文奖 “Elsevier/SETAC Best Student Presentations”(2006年)。

英文著作(Book Chapter)

1.Zhang, X., Giesy J., Hecker, M. (2013). Cell Lines in Aquatic Toxicology. In: J.F. Férard, C. Blaise, (eds.): Encyclopedia of Aquatic Ecotoxicology,Springer Publishers, Dordrecht, The Netherlands. pp 259-268
2.Zhang, X., Wiseman S, Giesy J. (2012) Toxicology of Water. In: A. Luch (ed): Molecular, Clinical and Environmental Toxicology Vol. III. Environmental Toxicology. Birkhäuser, Berlin. Germany.101:21-46. doi: 10.1007/978-3-7643-8340-4_2. .

代表SCI论文

2013年
XWZ-1)Zhang R, Manning GE, Farmahin R, Crump D, Zhang X*, Kennedy SW. 2013. Relative potencies of aroclor mixtures derived from avian in vitro bioassays: comparisons with calculated toxic equivalents. Environ Sci Technol. 47(15): 8852-61
XWZ-2)Escher BI, Allinson M, Altenburger R, Bain PA, Balaguer P, Busch W, Crago J, Denslow ND, Dopp E, Hilscherova K, Humpage AR, Kumar A, Grimaldi M, Jayasinghe BS, Jarosova B, Jia A, Makarov S, Maruya KA, Medvedev A, Mehinto AC, Mendez JE, Poulsen A, Prochazka E, Richard J, Schifferli A, Schlenk D, Scholz S, Shiraishi F, Snyder S, Su G, Tang JY, Burg BV, Linden SC, Werner I, Westerheide SD, Wong CK, Yang M, Yeung BH, Zhang X, Leusch FD. Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays. Environ Sci Technol. 2013 Dec 26. [Epub ahead of print]
XWZ-3)Zhang R, Sun J, Zhang Y, Cheng S, Zhang X*. 2013. Signal transduction disturbance related to hepatocarcinogenesis in mouse by prolonged exposure to Nanjing drinking water. Environ Sci Pollut Res Int. [In print]
XWZ-4)Su G, Zhang X*, Raine JC, Xing L, Higley E, Hecker M, Giesy JP, Yu H.(2013).Mechanisms of toxicity of triphenyltin chloride (TPTC) determined by a live cell reporter array. Environ Sci Pollut Res Int. 20(2): 803-11
XWZ-5)Fu J, Hu X, Tao X, Yu H, Zhang X*. 2013. Risk and toxicity assessments of heavy metals in sediments and fishes from the Yangtze River and Taihu Lake, China. Chemosphere 93(9): 1887-95.
XWZ-6)Xia J, Su G, Zhang X*, Shi W, Giesy JP, Yu H.2013.Dioxin-like activity in sediments from Tai Lake, China determined by use of the H4IIE-luc bioassay and quantification of individual AhR agonists. Environ Sci Pollut Res Int. [In print]
XWZ-7)Liu C, Yu H, Zhang X*. 2013. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 93(10), 2327–2332.
XWZ-8)Fu J, Wang Q, Wang H, Yu H, Zhang X*. 2013. Monitoring of non-destructive sampling strategies to assess the exposure of avian species in Jiangsu Province, China to heavy metals. Environ Sci Pollut Res Int. (In Press)
XWZ-9)Hu X, Shi W, Wei S, Zhang X, Feng J, Hu G, Chen S, Giesy JP, Yu H. 2013. Occurrence and Potential Causes of Androgenic Activities in Source and Drinking Water in China. Environ Sci Technol. 47(18): 10591-600
XWZ-10)Wang X, Yang H, Hu X, Zhang X, Zhang Q, Jiang H, Shi W, Yu H. 2013. Effects of HO-/MeO-PBDEs on Androgen Receptor: In Vitro Investigation and Helix 12-Involved MD Simulation. Environ Sci Technol. 47 (20), pp 11802–11809
XWZ-11)Yu N, Shi W, Zhang B, Su G, Feng J, Zhang X, Wei S, Yu H. 2013. Occurrence of perfluoroalkyl acids including perfluorooctane sulfonate isomers in Huai River Basin and Taihu Lake in Jiangsu Province, China. Environ Sci Technol. 47(2): 710-7.
XWZ-12)Xing L, Liu H, Zhang X, Hecker M, Giesy JP, Yu H. 2013. A comparison of statistical methods for deriving freshwater quality criteria for the protection of aquatic organisms. Environ Sci Pollut Res Int. [In print]
XWZ-13)Chen Y, Huang J, Xing L, Liu H, Giesy JP, Yu H, Zhang X. 2013. Effects of multigenerational exposures of D. magna to environmentally relevant concentrations of pentachlorophenol. Environ Sci Pollut Res Int. [In print]
XWZ-14)Yang Y, Maxwell A, Zhang X, Wang N, Perkins EJ, Zhang C, Gong P. (2013). Differential reconstructed gene interaction networks for deriving toxicity threshold in chemical risk assessment. BMC Bioinformatics. 2013;14 Suppl 14:S3. doi: 10.1186/1471-2105-14-S14-S3
XWZ-15)Liu C, Wang Q, Liang K, Liu J, Zhou B, Zhang X, Liu H, Giesy JP, Yu H. 2013. Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Aquat Toxicol. 128-129:147-57.
2012年
XWZ-16)Su G, Xia J, Liu H, Lam MH, Yu H, Giesy JP, Zhang X*.(2012) Dioxin-like Potency of OH- and MeO Analogues of PBDEs' the Potential Risk through Consumption of Fish from Eastern China. Environ Sci Technol. 46(19): 10781-8.
XWZ-17)Su G, Zhang X*, Liu H, Giesy J, Lam M, LAM P, Siddiqui M, Musarrat J, Al-Khedhairy A, Yu H. (2012) Toxicogenomic Mechanisms of 6-HO-BDE-47, 6-MeO-BDE-47 and BDE-47 in E. Coli" Environ Sci Technol. 46(2): 1185-91.
XWZ-18)Shi W, Hu X, Zhang F, Hu G, Hao Y, Zhang X*, Liu H, Wei S, Wang X, Giesy JP, Yu H.(2012) Occurrence of thyroid hormone activities in drinking water from eastern China: contributions of phthalate esters. Environ Sci Technol. 46(3): 1811-8.
XWZ-19)Su G, Liu X, Gao Z, Xian Q, Feng J, Zhang X*, Giesy JP, Wei S, Liu H, Yu H. (2012) Dietary intake of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) from fish and meat by residents of Nanjing, China. Environ Int. 42:138-43.
XWZ-20)Shi W, Zhang FX, Hu GJ, Hao YQ, Zhang XW, Liu HL, Wei S, Wang XR, Giesy JP, Yu HX. (2012) Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environ Int. 42:117-23.
XWZ-21)Law AY, Wei X, Zhang X, Mak NK, Cheung KC, Wong MH, Giesy JP, Wong CK. (2012) Biological analysis of endocrine-disrupting chemicals in animal meats from the Pearl River Delta, China. J Expo Sci Environ Epidemiol. 22(1):93-100.
XWZ-22)Ma Y, Han J, Guo Y, Lam PK, Wu RS, Giesy JP, Zhang X, Zhou B. (2012) Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquat Toxicol. 106-107:173-81.
XWZ-23)Liu C, Yan W, Zhou B, Guo Y, Liu H, Yu H, Giesy JP, Wang J, Li G, Zhang X*. (2012) Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat Toxicol. 2012 Apr 10;118-119:108-115.
XWZ-24)Xing L, Liu H, Giesy JP, Zhang X, Yu H. (2012). Probabilistic ecological risk assessment for three chlorophenols in surface waters of China. J Environ Sci (China). 24(2):329-34.
XWZ-25)Bursian SJ, Moore J, Newsted JL, Link JE, Fitzgerald SD, Bello N, Bhat VS, Kay D, Zhang X, Wiseman S, Budinsky RA, Giesy JP, Zwiernik MJ. (2012) Incidence of jaw lesions and activity and gene expression of hepatic P4501A enzymes in mink (Mustela vison) exposed to dietary 2,3,7,8-tetrachlorodibenzo-P-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. Environ Toxicol Chem. 2012 Aug 3. doi: 10.1002/etc.1975.
2011年
XWZ-26)Zhang X*, Chang H, Wiseman S, He Y, Higley E, Jones P, Wong CK, Al-Khedhairy A, Giesy J, Hecker M. (2011). Bisphenol A Disrupts Steroidogenesis in Human H295R Cells. Toxicol Sci. 121(2), 320–327.
XWZ-27)Zhang X*, Wiseman S, Yu H, Liu H, Giesy JP, Hecker M. (2011). Assessing the toxicity of naphthenic acids using a microbial genome wide live cell reporter array system. Environ Sci & Technol. 45(5):1984-91.
XWZ-28)Han Z, Jiao S, Kong D, Shan Z, Zhang X*. (2011) Effects of β-endosulfan on the growth and reproduction of zebrafish (Danio rerio). Environ Toxicol Chem. 30(11): 2525-31
XWZ-29)Liu C, Zhang X, Deng J, Hecker M, Al-Khedhairy A, Giesy JP, Zhou B. (2011). Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA, and HPT axes in zebrafish. Environ Sci Technol. 45(2):769-75.
XWZ-30)He Y, Wiseman SB, Hecker M, Zhang X, Wang N, Perez LA, Jones PD, Gamal El-Din M, Martin JW, Giesy JP. (2011) Effect of Ozonation on the Estrogenicity and Androgenicity of Oil Sands Process-Affected Water. Environ Sci Technol. 45(15): 6268-74
XWZ-31)Shi W, Wang X, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Yu H.(2011) Bioanalytical and instrumental analysis of thyroid hormone disrupting compounds in water sources along the Yangtze River. Environ Pollut. 159(2):441-8.
XWZ-32)Zhang F, Hu W, Yu H, Sun H, Shen O, Wang X, Liu H, Lam MH, Giesy JP, Zhang X. (2011). Endocrine disruption effects of 2,2',4,4',6-pentabromodiphenylether (BDE100) in reporter gene assays. J Environ Monit. 13(4):850-4.
XWZ-33)Ma Y, Liu C, Lam PK, Wu RS, Giesy JP, Hecker M, Zhang X, Zhou B. (2011). Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology. 282(3): 146-53.
XWZ-34)Liu H, Hu W, Sun H, Shen O, Wang X, Lam MH, Giesy JP, Zhang X, Yu H. (2011). In vitro profiling of endocrine disrupting potency of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogues (HO-PBDEs). Mar Pollut Bull. 63(5-12):287-96.
XWZ-35)Xi W, Lee CK, Yeung WS, Giesy JP, Wong MH, Zhang X, Hecker M, Wong CK. 2011. Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice. Reprod Toxicol. 31(4):409-17.
XWZ-36)Wiseman SB, Wan Y, Chang H, Zhang X, Hecker M, Jones PD, Giesy JP. (2011). Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: Environmental sources, metabolic relationships, and relative toxicities. Mar Pollut Bull. 63(5-12):179-88.
XWZ-37)Shi W, Zhang F, Zhang X, Su G, Wei S, Liu H, Cheng S, Yu H. (2011). Identification of trace organic pollutants in freshwater sources in Eastern China and estimation of their associated human health risks. Ecotoxicology. 20(5):1099-106.
XWZ-38)Gopalakrishnan S, Nai Z, Thilagam H, Bei C, Ding J, Wang XH, Wang WX, Ke CH, Giesy JP, Zhang X, Wang KJ. (2011) Biochemical responses and DNA damage in red sea bream from coastal Fujian Province, China. Ecotoxicol Environ Saf. 74(6):1526-35
XWZ-39)Vardy DW, Tompsett AR, Sigurdson JL, Doering JA, Zhang X, Giesy JP, Hecker M. (2011) Effects of sub-chronic exposure of early life stages of white sturgeon (Acipenser transmontanus) to copper, cadmium, and zinc. Environ Toxicol Chem. 30(11): 2497-505
XWZ-40)Hu W, Liu H, Sun H, Shen O, Wang X, Lam MH, Giesy JP, Zhang X, Yu H. (2011) Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. Mar Pollut Bull. 62(11): 2356-61
XWZ-41)Huang C, Wu S, Zhang X, Chang H, Zhao Y, Giesy JP, Hu J. (2011) Modulation of estrogen synthesis through activation of protein kinase A in H295R cells by extracts of estuary sediments. Environ Toxicol Chem. 30(12):2793-801
XWZ-42)Nichols JW, Breen M, Denver RJ, Distefano JJ 3rd, Edwards JS, Hoke RA, Volz DC, Zhang X.(2011). Predicting chemical impacts on vertebrate endocrine systems. Environ Toxicol Chem. 30(1):39-51.
2010年
XWZ-43)Wan Y, Liu F, Wiseman S, Zhang X*, Chang H, Hecker M, Jones PD, Lam MH, Giesy JP. (2010). Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka. Environ Sci Technol. 2010 Nov 15; 44(22): 8729-35.
XWZ-44)Liu, C., Zhang, X*., Chang, H., Jones, P., Wiseman, S., Naile, J., et al. (2010). Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signalling cascade. Toxicology and Applied Pharmacology, 247(3), 222-228.
XWZ-45)Chang, H., Wan, Y., Naile, J., Zhang, X., Wiseman, S., Hecker, M., et al. (2010). Simultaneous quantification of multiple classes of phenolic compounds in blood plasma by liquid chromatography-electrospray tandem mass spectrometry. Journal of Chromatography A, 1217(4), 506-513.
XWZ-46)Higley, E. B., Newsted, J. L., Zhang, X., Giesy, J. P., & Hecker, M. (2010). Assessment of chemical effects on aromatase activity using the H295R cell line. Environmental Science and Pollution Research, 17(5), 1137-1148.
XWZ-47)Han, S., Choi, K., Kim, J., Ji, K., Kim, S., Ahn, B., Zhang, X., et al. (2010). Endocrine disruption and consequences of chronic exposure to ibuprofen in japanese medaka (oryzias latipes) and freshwater cladocerans daphnia magna and moina macrocopa. Aquatic Toxicology, 98(3), 256-264.
XWZ-48)He, Y., Wiseman, S. B., Zhang, X., Hecker, M., Jones, P. D., El-Din, M. G., et al. (2010). Ozonation attenuates the steroidogenic disruptive effects of sediment free oil sands process water in the H295R cell line. Chemosphere, 80(5), 578-584.
XWZ-49)Brinkmann, M., Hudjetz, S., Cofalla, C., Roger, S., Kammann, U., Giesy, J. P., Zhang, X., et al. (2010). A combined hydraulic and toxicological approach to assess re-suspended sediments during simulated flood events. part I-multiple biomarkers in rainbow trout. Journal of Soils and Sediments, 1-15.
XWZ-50)Ji, K., Choi, K., Lee, S., Park, S., Khim, J. S., Jo, E., Zhang, X., et al. (2010). Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish oryzias latipes. J Hazardous Materials, 182(1-3), 494-502.
2010年之前
XWZ-51)Zhang, X*., Newsted, J. L., Hecker, M., Higley, E. B., Jones, P. D., & Giesy, J. P. (2009). Classification of chemicals based on concentration-dependent toxicological data using ToxClust. Environ Sci & Technol, 43(10), 3926-3932.
XWZ-52)Zhang, X*., Hecker, M., Jones, P. D., Newsted, J., Au, D., Kong, R., et al. (2008). Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. Environ Sci & Technol, 42(17), 6762-6769.
XWZ-53)Zhang, X*., Yu, R. M. K., Jones, P. D., Lam, G. K. W., Newsted, J. L., Gracia, T., et al. (2005). Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line. Environ Sci & Technol, 39(8), 2777-2785.
XWZ-54)Zhang, X*., Hecker, M., Park, J. -., Tompsett, A. R., Newsted, J., Nakayama, K., et al. (2008). Real-time PCR array to study effects of chemicals on the hypothalamic-pituitary-gonadal axis of the japanese medaka. Aquat Toxicol, 88(3), 173-182.
XWZ-55)Zhang, X*., Hecker, M., Park, J. -., Tompsett, A. R., Jones, P. D., Newsted, J., et al. (2008). Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (oryzias latipes) exposed to fadrozole and 17β-trenbolone. Environmental Toxicology and Chemistry, 27(12), 2504-2511.
XWZ-56)Zhang, X., Moore, J. N., Newsted, J. L., Hecker, M., Zwiernik, M. J., Jones, P. D., et al. (2009). Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of mink (mustela vison) to facilitate study of dioxin-like compounds. Toxicol & Appl Pharmacol, 234(3), 306-313.
XWZ-57)Zhang, X., Wu, R. S. S., Fu, W., Xu, L., & Lam, P. K. S. (2004). Production of reactive oxygen species and 8-hydroxy-2′deoxyguanosine in KB cells co-exposed to benzo[a]pyrene and UV-A radiation. Chemosphere, 55(10), 1303-1308.
XWZ-58)Wan, Y., Wiseman, S., Chang, H., Zhang, X., Jones, P. D., Hecker, M., et al. (2009). Origin of hydroxylated brominated diphenyl ethers: Natural compounds or man-made flame retardants? Environ Sci & Technol, 43(19), 7536-7542.
XWZ-59)Hilscherova, K., Jones, P. D., Gracia, T., Newsted, J. L., Zhang, X., Sanderson, J. T., et al. (2004). Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicol Sci, 81(1), 78-89.
XWZ-60)So, M. K., Zhang, X., Giesy, J. P., Fung, C. N., Fong, H. W., Zheng, J., et al. (2005). Organochlorines and dioxin-like compounds in green-lipped mussels perna viridis from hong kong mariculture zones. Marine Pollution Bulletin, 51(8-12), 677-687.
XWZ-61)Fung, C. N., Zheng, G. J., Connell, D. W., Zhang, X., Wong, H. L., Giesy, J. P., et al. (2005). Risks posed by trace organic contaminants in coastal sediments in the pearl river delta, china. Marine Pollution Bulletin, 50(10), 1036-1049.
XWZ-62)Xu, Y., Yu, R. M. K., Zhang, X., Murphy, M. B., Giesy, J. P., Lam, M. H. W., et al. (2006). Effects of PCBs and MeSO2-PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells. Chemosphere, 63(5), 772-784.
XWZ-63)Gracia, T., Hilscherova, K., Jones, P. D., Newsted, J. L., Zhang, X., Hecker, M., et al. (2006). The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicology and Environmental Safety, 65(3), 293-305.
XWZ-64)Gracia, T., Hilscherova, K., Jones, P. D., Newsted, J. L., Higley, E. B., Zhang, X., et al. (2007). Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicology and Applied Pharmacology, 225(2), 142-153.
XWZ-65)Gracia, T., Jones, P. D., Higley, E. B., Hilscherova, K., Newsted, J. L., Murphy, M. B., Zhang, X., et al. (2008). Modulation of steroidogenesis by coastal waters and sewage effluents of hong kong, china, using the H295R assay. Environmental Science and Pollution Research, 15(4), 332-343.
XWZ-66)Park, J., Tompsett, A., Zhang, X., Newsted, J. L., Jones, P. D., Au, D., et al. (2008). Fluorescence in situ hybridization techniques (FISH) to detect changes in CYP19a gene expression of japanese medaka (oryzias latipes). Toxicology and Applied Pharmacology, 232(2), 226-235.
XWZ-67)Moore, J. N., Newsted, J. L., Hecker, M., Zwiernik, M. J., Fitzgerald, S. D., Kay, D. P., Zhang, X., et al. (2009). Hepatic p450 enzyme activity, tissue morphology and histology of mink (mustela vison) exposed to polychlorinated dibenzofurans. Archives of Environmental Contamination and Toxicology, 57(2), 416-425.
XWZ-68)Tompsett, A. R., Park, J. W., Zhang, X., Jones, P. D., Newsted, J. L., Au, D. W. T., et al. (2009). In situ hybridization to detect spatial gene expression in medaka. Ecotoxicology and Environmental Safety, 72(4), 1257-1264.
XWZ-69)Park, J. -W., Tompsett, A. R., Zhang, X., Newsted, J. L., Jones, P. D., Doris, W. T. A., et al. (2009). Advanced fluorescence in situ hybridization to localize and quantify gene expression in japanese medaka (oryzias latipes) exposed to endocrine-disrupting compounds. Environ Toxicol and Chem, 28(9), 1951-1962.

美国专利

l XWZ-1) Zhang X.*, Hecker, M. and Giesy, J.P. Steroidogenesis modified cells and methods for screening for endocrine disrupting chemicals (Patent Number: US 08299238)

会议报告

2006年以来发表会议报告摘要54篇,其中做大会特邀报告5次,受邀报告9 篇。
Society of Environmental Toxicology and Chemistry (SETAC) - North America
(1)Toxicogenomic Screening of Environmental Pollutants on Toxicity. To: SETAC NORTH AMERICA 33rd ANNUAL MEETING, LONG BEACH, CALIFORNIA, NOV 11-15, 2012
(2)Application of an E.coli live cell array system in ecotoxicity assessment To: 32st Annual Meeting 13-17 November 2011. Boston, MA, USA.
(3)“Evaluation of the Endocrine Disrupting Potential of the Binary Exposure to Trilostane and Prochloraz in H295R Cells and Medaka Fish.” To: 31st Annual Meeting 7-11 November 2010. Portland, OR, USA.
(4)“Assessing the Cellular Effects of Naphthenic Acids Using a High Throughput Microbial Gene Profiling System.” To the 31st Annual Meeting 7-11 November 2010. Portland, OR, USA.
(5) “New evidence for the Natural Origin of Hydroxylated PBDEs.” With: Wiseman et al. To the 31st Annual Meeting 7-11 November 2010. Portland, OR, USA.
(6) “Assessing the Endocrine Disruptive Effects of OSPW: Effects of Sex Hormone Steroidogenesis and Receptor Signalling in vitro.” With: He et al. To: 31st Annual Meeting 7-11 November 2010. Portland, OR, USA.
(7)“The effects of TCDD, PeCDF and TCDF on development of maxillary and mandibular squamous epithelial proliferation in mink” With J. Moore, et al. To: 30th Annual Meeting. 19-23 November 2009. New Orleans, LA, USA.
(8)“The effects of TCDD, PeCDF and TCDD on reproduction of mink and growth and survivability of their offspring” With J. Moore, et al. To: 30th Annual Meeting. 19-23 November 2009. New Orleans, LA, USA.
(9)“Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-made Flame Retardants? ” With Wan, Y., et al. To: 30th Annual Meeting. 19-23 November 2009. New Orleans, LA, USA.
(10)“Canidae Exposure to Polychlorinated Dibenzofurans (PCDFs) of the Tittabawassee River Floodplain, Midland, MI” With J. Moore, et al. To: 30th Annual Meeting. 19-23 November 2009. New Orleans, LA, USA.
(11)“Effects of Ozone-Treated and Untreated Sediment-Free Oil Sand Processed Water on In Vitro Steroidogenesis ” With Y. He, et al. To: 30th Annual Meeting. 19-23 November 2009. New Orleans, LA, USA.
(12)“Testing and Risk Assessment of Chemicals that Impact Highly Adaptive Biological Systems: The Case of Endocrine Systems” With J. Nichols, et al. To: 30th Annual Meeting. 19-23 November 2009. New Orleans, LA, USA.
(13)"Application of a medaka HPG axis real time PCR array method to environmental chemical screening." To: 29th Annual Meeting. 16-20 November 2008. Tampa, FL, USA.
(14)"Characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study on dioxin-like compounds" To: 29th Annual Meeting. 16-20 November 2008. Tempa, FL, USA.
(15)“White sturgeon growth, morphology, and survival after exposure to Columbia River surface water at two sites in British Columbia, Canada.” With A.R. Tompsett, D. Vardy, M. Hecker, S. Wiseman, K. Liber, J.P. Giesy. To: 29th Annual Meeting. 16-20 November 2008. Tampa, FL, USA.
(16)“Testing of five model endocrine disrupting chemicals using medaka hypothalamic- pituitary-gonadal (BHG) axis model and RT-PCR array method”. To: 28th Annual Meeting, November 11-15, 2007, Milwaukee, WS, USA. Invited
(17)“Gene Expression and Histological Structure as Biomarkers of Chemical Exposure in Japanese Medaka.” With AR. Tompsett, J. Park, M. Hecker, P.D. Jones, J.L. Newsted, D. Au and J. Giesy. To: 28th Annual Meeting, November 11-15, 2007, Milwaukee, WS. USA. Invited
(18)“Development and Validation of a Quantitative Real Time RT-PCR System to Study Chemical Induced Effects on the HPG-axis of Medaka (Oryzias latipes)”. To: 27th Annual Meeting, November 5-9, 2006, Montreal, Canada.
(19)“A mixture model for chemical clustering --- an application using data from H295R cell assays”. To: 27th Annual Meeting, November 5-9, 2006. Montreal, Canada.
(20)”Elucidating Changes in Aromatase (CYP19) Gene Expression in Japanese Medaka (Oryzias latipes) Exposed to Fadrozole: Q RT-PCR and its comparison with ISH methods”. With J. Park, A.Tompsett, M. Hecker, P.D. Jones, J.L and J.Giesy. Newsted. To: 27th Annual Meeting, November 5-9, 2006, Montreal, Quebec, Canada.
(21)“Data Analysis Approaches for Interpreting Complex Toxicogenomic Data Sets.” With P.D. Jones, J.L. Newsted, T. Gracia, J.T Sanderson, K. Hilscherova and J. Giesy. To: 27th Annual Meeting, November 5-9, 2006, Montreal, Quebec, Canada.
(22)“Multiplex in situ Hybridization to Detect CYP19a and b Gene Expression Patterns Along the HPG-axis of the Japanese Medaka (Oryzias latipes).” With J. Park, A.R. Tompsett, M. Hecker, P.D Jones, and J.L. Newsted and J Giesy.. To: 27th Annual Meeting, November 5-9, 2006, Montreal, Quebec, Canada.
(23)“A Comparison of H295R, R2C and JEG-3 Cells as Screening Tools for Effects on Steroidogenesis”. To: 26th Annual Meeting, November 13-17, 2005, Baltimore, MD.
(24)“Quantitative Assessment of Chemical Effects on Steroidigenic Enzymes in H295R Cells Line Using Q-RT-PCR”. With: T. Gracia, K. Hilscherova, P. D. Jones, J. T. Sanderson and J. L. Nested and J. Giesy. To: 25th Annual Meeting, November 14-18, 2004, Portland, Oregon.
(25)“A Cell Culture Based Assay for the Measurement of Xenobiotic Effects on Steroid Production”. With: P. D. Jones, M. Heckeer, T. Gracia, J. T. Sanderson and J. L. Newsted and J. Giesy. To: 25th Annual Meeting, November 14-18, 2004, Portland, Oregon.
SETAC-Europe
(26)“Evaluation of the Endocrine-Disrupting Potential of Bisphenol A Using the H295R Steroidogenesis Assay and Small Fish Model”. To: 19th Annual Meeting, 31 May- 4 June, 2009, Göteborg, Sweden.
(27)“Development of a H295R Cell Line Test to Evaluate Toxicant-Induced Effects on Steroidogenesis”. With M. Hecker, M. Murphy, T. Gracia, P. Jones, T. Sanderson, J. Newsted and J Giesy. To: 15th Annual Meeting, May 22-26, 2005, Lille, France.
(28)“Effects of Chemicals on Steroidogenesis in H295R Cells”. With T. R. Gracia, K. Hilscherova, P. D. Jones, J.T. Sanderson, J.L. Newsted and J. Giesy. To: 14th Annual Meeting, April 18-22, 2004, Prague, Czech Republic.
(29)“Evaluating toxicant-induced effects on steroidogenesis using the H295R cell line”. To: 14th Annual Meeting of the, May 2004. Prague, Czech.
(30)“Effect of benzo[a]pyrene and ultraviolet A on KB cells: relationship between ROS production and 8-Hydroxy-2'deoxyguanosine (8-OHdG) formation”. To: 12th Annual Meeting, Vienna, Austria. May 2002.
SETAC-Asia/Pacific
(31)“Mechanistic evaluation of the effects of environmental pharmaceuticals”. To: SETAC Asia/Pacific 2010, Guangzhou, China June 4-7, 2010

SETAC-Ohio Valley Chapter
(32)“Comparison on the toxicity profile of PFOA and PFOS using genomic data”. To: 23rd Annual Meeting. Fort Waney, Indiana, USA. 20-21, Apr 2006.
International Science Forum on Computational Toxicology 2007
(33)“Human adrenocarcinoma (H295R) cells for the rapid in vitro determination of effects on steroidogenesis: gene expression, sex steroid concentrations, and aromatase activity”. With N., John, M. Hecker and J. Giesy. 21–23, May 2007. Research Triangle Park, North Carolina, USA.
Society of Toxicology
(34)“Profiling Gene Expression in Human H295R Adrenocortical Carcinoma Cells and Rat Testes to Identify Pathways of Toxicity for Conazole Fungicides”. With H. Re, J. E. Schmid, J. Retief, Y. Turpaz, X. Zhang, P. D. Jones, J. L. Newsted, J. P. Giesy, D. C. Wolf, C. R. Wood, W. Bao and D. J. Dix. To: 44th Annual Meeting, March 6-10, 2005, New Orleans.
Dioxin Conference 2008
(35)Characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 in mink (mustela vison) exposed to polychlorinated dibenzofurans (PCDFs) With Jeremy N. Moore, John L. Newsted, Matthew J. Zwiernik, Markus Hecker, Paul D. Jones, Steven J. Bursian, John P. Giesy. 17-22, August 2008, Birmingham, UK.
(36)“Gene expression and histological structure as biomarkers of chemical exposure in Japanese medaka.” With A. Tompsett, J.-W. Park, J.L. Newsted, M. Hecker, P.D. Jones and J. Giesy. 34th Aquatic Toxicity Workshop, Halifax, Nova Scotia, October 2, 2007.
 
Aquatic Toxicology Workship, Canada
(37)“Evaluation of Environmental Endocrine Disrupting Chemicals Using Japanese Medaka HPG axis model”. To 35th Aquatic Toxicology Workshop, Saskatoon, SK. Oct 5-10, 2008.
Others
(38)“Elucidating Changes in Aromatase (CYP19) Gene Expression in Japanes Medaka (Oryzias latipes) Exposed to Fadrazol: In situ Hybridization in a Whole Animal Model. With A. Tompsett, J.W. Park, M. Hecker, J.L. Newsted, P.D. Jones, D. Au, P.K.S. Lam, R. S.S. Wu and J. Giesy. To: Institute of Oceanography, Chinese Academy of Sciences, and State Key Laboratory of Marine Ecology & Environmental Sciences, Qingdao, PR China, January 9, 2007. Invited
(39)“Development of a H295R Cell Screening Test to Evaluate Toxicant-Induced and Hypoxic Effects on Steroidogenesis”. . With M. Hecker, M. Murphy, T. Gracia, P.D. Jones, X. Zhang, J.L. Newsted, R. Yu, R.S.S. Wu and J.Giesy. To: Symposium, Centre for Marine Pollution and Environmental Research and Innovative Technology, City University of Hong Kong, Kowloon, Hong Kong, China, November 30-December 1, 2005.
(40)“Mechanistic classification of environmental endocrine disrupting chemicals”. The 5th international conference on marine pollution and ecotoxicology. Hong Kong, P. R. China, 3-6, Jun, 2007
(41)“Evaluation of Environmental Endocrine Disrupting Chemicals Using the Medaka HPG Axis Model” The The 5th International Symposium on Persistent Toxic Substances. Beijing, P.R. China, September 21-24, 2008
(42)“Toxicity pathway-based approaches to evaluate the impact of environmental chemicals.” International Conference on Water Pollution & Management. Suzhou, China May 23 – 27, 2009 (Invited Plenary Keynote)
(43)“Endocrine Disruptor Mechanisms and Screening: Beyond Receptor Binding”. With J. Giesy, M. Hecker, and D. Au. To: International Conference on Water Pollution and Management, May 23-27, Suzhou, China. Invited Plenary Keynote
(44)“Integrative Approaches and Strategies to Solve Environmental Issues:---from Molecules to Population”. To: The Second Winter Symposium on Emerging and Persistent Organic Pollutants, Organized by the Korea POPs Forum (KPF), Gyeong-Ju, Korea. February 16 to 18, 2011. (Invited Plenary Keynote)
(45)Assessing The Chemical Induced Toxicity Using A Microbial Genome Wide Live Cell Reporter Array System. To: 15th International Symposium on Toxicity Assessment, Hong Kong China. 3-8 July, 2011(Invited)
(46)Application Of An E.Coli Live Cell Array System In Ecotoxicity Assessment. To: The 2nd Conference Of The Sino-Finnish Environmental Research Centre (Sferc) On Challenges Of Environmental Research And Management (2011) Joensuu, Finland 21-23 Aug, 2011
(47)Integrative Approaches and Strategies to Solve Environmental Issues:
---from Molecules to Population. To: the visiting Professor program, King Saud University, Riyadh, Kingdom of Saudi Arabia, Oct 16-22, 2011 (Invited seminar)
(48)Emerging Advancements in Toxicology & Environmental Science Integrating -Omic Technologies. To: the visiting Professor program, King Saud University, Riyadh, Kingdom of Saudi Arabia, Oct 16-22, 2011 (Invited seminar)
(49)Evolving predictive ecotoxicological approaches for development of water quality standards in the 21st century. To: International Conference on Deriving Environmental Quality Standards for the Protection of Aquatic Ecosystems (EQ·SPAE – 2011), Hong Kong. 3-7 December 2011. (Invited Plenary Keynote)
(50)Toxicogenomic Screening of Environmental Pollutants on Toxicity. To: the joint conference of Korean Society of Environmental Health and Korean Society of Toxicology which will be held in Samsung Convention Center, Seoul, National Univeristy, Seoul Korea on May 31 and June 1, 2012. (Invited)
(51)Toxicogenomic Screening of Environmental Pollutants on Toxicity. To: the 21st (Japanese) Symposium of Environmental Chemistry in Matsuyama, Ehime, Japan. July 10-13, 2012. (Invited)
(52)The role of Predictive Ecotoxicology in the development of test assays and ecological criteria of chemicals To: International Conference on Environmental Safety and Ecological Criteria/Standard, Nanjing, July 1,2013 (Invited)
(53)Exposure, Toxicity and Risk Estimation of PBDE analogues in Environment. To: 2013 International Workshop on Risk Management and Control of Chemicals, Dalian, October 13-16, 2013. (Invited Plenary Keynote)
(54)Exposure, Toxicity and Risk Estimation of PBDE analogues in Environment. To: 7th International Conference on Marine Pollution and Ecotoxicology, June 22-24, Hong Kong 2013. (Invited Keynote)

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