准聘副教授、国家级青年人才、博士生导师

地址：南京大学环境学院B411室

Email: zhigang.yu@@nju.edu.cn

教育与工作经历

研究领域

围绕微生物耐药性研究领域，开展：（1）环境抗生素风险评估；（2）病原微生物耐药毒力进化;（3）饮用水消毒；（4）药物-肠道健康；（5）建筑环境与人体暴露

学术兼职

l   Biocontaminant期刊副主编

l   国际微生物生态协会ISME会员、ISME早期职业科学家委员会会员

l   Microorganisms、Frontier in Microbiology等期刊客座编辑

l   ISME J、ISME Commun、ES&T、WR等20+期刊审稿人

科研项目

1. 澳大利亚研究理事会连接项目（LP），饮用水管道系统生物膜中病原体研究, lead CI

2. 昆士兰大学研究捐赠项目，复杂微生物群落中细菌抗菌素抗性的传播, 主持

3. 澳大利亚研究理事会早期职业研究者项目(DECRA)，城市水系统中细菌耐药性进化,主持

近五年代表性论文

1. Yujie Li, Zhigang Yu*, Yuanyuan Kang, Shan Wu, Jan Engelstädter, Gilda Carvalho, Damien Batstone, and Jianhua Guo*. Chlorination Enhances Bacterial Invasion and Conjugative Transfer of Antibiotic Resistance Genes in Biofilms. Environmental Science & Technology 33, no. 60 (2026): 23148-23161.

2. Yujie Li, Zhigang Yu*, Gilda Carvalho, and Jianhua Guo. Optimising disinfection conditions to cover antimicrobial resistance: mechanistic insights, safe dosage threshold and genomic indicators. Current Opinion in Chemical Engineering 54 (2026):10129.

3. Zhigang Yu, Michael Gillings, Nicholas J. Ashbolt, and Jianhua Guo*. Antimicrobial resistance in complex microbiomes: ecological evolution and public health risks. Biocontaminant 1, no. 1 (2025).

4. Zhigang Yu, Emily CA Goodall, Ian R. Henderson, and Jianhua Guo*. Plasmids can shift bacterial morphological response against antibiotic stress. Advanced Science 10, no. 2 (2023): 2203260.

5. Zhigang Yu, Ian R. Henderson, and Jianhua Guo*. Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota. Gut Microbes 15, no. 1 (2023): 2157698. (Highly cited paper)

6. Wang Yue, Zhigang Yu^#, Pengbo Ding, Ji Lu, Likai Mao, Lyman Ngiam, Zhiguo Yuan, Jan Engelstädter, Mark A. Schembri, and Jianhua Guo*. Antidepressants can induce mutation and enhance persistence toward multiple antibiotics. Proceedings of the National Academy of Sciences 120, no. 5 (2023): e2208344120. (Highly cited paper)

7. Zhigang Yu, Yue Wang, Ian R. Henderson, and Jianhua Guo*. Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation. The ISME Journal 16, no. 2 (2022): 543-554. (Editors’ Choice)

8. Zhigang Yu, and Jianhua Guo*. Non-caloric artificial sweeteners exhibit antimicrobial activity against bacteria and promote bacterial evolution of antibiotic tolerance. Journal of Hazardous Materials 433 (2022): 128840.

9. Zhigang Yu, Xuemei Li, and Jianhua Guo*. Combat antimicrobial resistance emergence and biofilm formation through nanoscale zero-valent iron particles. Chemical Engineering Journal 444 (2022): 136569.

10. Yue Wang^#, Zhigang Yu^#, Pengbo Ding, Ji Lu, Uli Klümper, Aimee K. Murray, William H. Gaze, and Jianhua Guo*. Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level. Microbiome 10, no. 1 (2022): 124.

11. Zhigang Yu, Yue Wang, Ji Lu, Philip L. Bond, and Jianhua Guo*. Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer. The ISME Journal 15, no. 7 (2021): 2117-2130. (Highly cited paper; Best Paper Award Winner)

12. Zhigang Yu, Hesamoddin Rabiee, and Jianhua Guo*. Synergistic effect of sulfidated nano zerovalent iron and persulfate on inactivating antibiotic resistant bacteria and antibiotic resistance genes. Water Research 198 (2021): 117141.

注：^#为共同一作；*为通讯作者

科技奖励

l   2022澳大利亚水协会昆士兰州最佳学生奖

l   2021年度国家优秀自费留学生奖学金

l   2021年度ISME最佳论文奖（全球仅3篇）

l   2018年昆士兰大学博士生全额奖学金

招生情况

欢迎具有环境、生物、计算机、材料等多学科交叉背景的有研究热情的博士后、博士/硕士研究生、本科生加入。