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副教授

史薇

博士,副教授
南京大学环境学院环境化学专业

联系方式

南京市栖霞区仙林大道163号,南京大学环境学院A511室
Email: njushiwei@nju.edu.cn

欢迎热爱有机污染化学、环境分析、环境生态毒性评价的同学报考研究生。我们同时招收博士后研究人员以及专职科研岗位,欢迎有意者联系。

主要学习经历

2007.9-2011.6 南京大学 环境化学,理学博士
2003.9-2007.6 南京大学 环境科学,理学学士

研究经历

2014.6- 南京大学,环境学院,副教授
2015.8-2016.8, 美国University of California, Riverside,访问学者
2011.8-2014.6 南京大学,环境学院,助理研究员

主要研究领域

1. 有机污染物在环境过程中的迁移、转化与毒性效应
2. 内分泌干扰物的高通量筛选与风险评估
3. 复合污染介质中有机毒物分级鉴别与生物可利用性

主持科研项目

(1)国家自然科学基金面上项目,21577058,基于生物富集转化过程及其仿生技术的水中抗雄激素活性物质鉴别评价研究,2016/01-2019/12,76万元,在研,主持;
(2)国家环保部公益性行业科研专项,201409040,水体沉积物毒性鉴定与生物测试标准方法体系研究(子课题),2014/01-2017/12,40万,在研,参加;
(3)国家自然科学基金青年科学基金项目,21307054,基于生物可利用机制的沉积物中拟雄激素活性物质鉴别研究,2014/01-2016/12,26万元,已结题,主持;
(4)江苏省自然科学基金青年项目,BK20130551,沉积物拟雄激素活性评价及毒物鉴别技术研究,2013/07-2016/07,20万元,已结题,主持;
(5)国家自然科学基金NSFC-TAMU合作项目, 21411120337,中美人群暴露于大气颗粒污染物的毒性标志物研究,2014/10-2015/09,5万元,已结题,主持;
(6)国家高技术研究发展计划(863计划)“典型化工区化学品风险甄别与控制综合示范”子课题,2013AA06A309,以效应为导向的关键致毒物质识别技术应用研究与示范,2013/01-2015/12, 150万元,已结题,主持。

近期发表论文、专利及软件(*通讯作者)

(1) Shi W, Yu N, Han Z, Wang S, Zhang X*, Wei S, Geisy J P, Yu H*. Influence of blooms of phytoplankton on concentrations of hydrophobic organic chemicals in sediments and snails in a hyper-eutrophic, freshwater lake, Water Research, 113: 22-31 2017
(2) Shi W, Guo J, Zhou Y, Deng D, Han Z, Zhang X*, Yu H*, Geisy J P. Phthalate Esters on Hands of Office Workers: Estimating Influence of Touching Surfaces. Environmental Science & Technology Letters, 4(1):1-5 2017
(3) Wang X, Zhang X, Xia P, Zhang J, Wang Y, Zhang R, Giesy J P, Shi W*, Yu H*. A high-throughput, computational system to predict if environmental contaminants can bind to human nuclear receptors. Science of the Total Environment, 576: 609-616 2017
(4) Fang B, Guo J, Li F, Giesy J P, Wang L*, Shi W*. Bioassay directed identification of toxicants in sludge and related reused materials from industrial wastewater treatment plants in the Yangtze River Delta. Chemosphere, 168: 191-198 2017
(5) Chen Q, Wang X, Shi W*, Yu H*, Zhang X, Geisy J P, Identification of thyroid hormone disruptors among HO-PBDEs: In vitro investigations and co-regulator involved simulations. Environmental Science & Technology, 50(22):12429-12438 2016
(6) Qu C, Shi W*, Guo J, Fang B, Wang S, Giesy J P, Holm P E, China’s Soil Pollution Control: Choices and Challenges, Environmental Science & Technology, 50 (24): 13181-13183 2016
(7) Shi W, Deng D, Wang Y, Hu G, Guo J, Zhang X, Wang X, Giesy J P, Yu H*, Wang Z. Causes of endocrine disrupting potencies in surface water in East China, Chemosphere, 144: 1435–1442 2016
(8) He X, Liu P, Zheng G, Chen H*, Shi W, Cui Y, Ren H, Zhang XX*. Evaluation of five microbial and four mitochondrial DNA markers for tracking human and pig fecal pollution in freshwater. Scientific Reports, 6:35311 2016
(9) SM Oskui, G Diamante, Liao C, Shi W, J Gan, D Schlenk, W.H.Grover*. Assessing and Reducing the Toxicity of 3D-Printed Parts. Environmental Science & Technology Letters, 3 (1):1–6 2016
(10) Hu X, Shi W*, Yu N, Jiang X, Wang S, Giesy J P, Zhang X, Wei S, Yu H*. Bioassay-directed identification of organic toxicants in water and sediment of Tai Lake, China, Water Research, 73(15), 231–241 2015
(11) He X, Chen H*, Shi W, Cui Y, Zhang XX*. Persistence of mitochondrial DNA markers as fecal indicators in water environments. Science of The Total Environment, 533:383-390 2015
(12) Hu G, Chen S, Shi W, Zhang B, Zhang Y, Huang J, Chen J, Giesy JP*, Yu H*. Identification of polycyclic aromatic hydrocarbons in soils in Taizhou, East China. Environmental Geochemistry and Health, 37(3):429–439 2015
(13) Yu N, Wang X, Zhang B, Yang J, Li M, Li J, Shi W, Wei S*, Yu H*. Distribution of perfluorooctane sulfonate isomers and predicted risk of thyroid hormonal perturbation in drinking water. Water Research, 76:171–180 2015
(14) Xia J, Su G, Zhang X*, Shi W, Giesy J P, Yu H. Dioxin-like activity in sediments from Tai Lake, China determined by use of the H4IIE-luc bioassay and quantification of individual AhR agonists, Environmental Science and Pollution Research, 21:1480–1488 2014
(15) Hu X, Shi W*, Wei S, Zhang X, Feng J, Hu G, Chen S, Giesy J P, Yu H*. Occurrence and potential causes of androgenic activities in source and drinking water in China, Environmental Science & Technology, 47 (18): 10591–10600 2013
(16) Wang X, Yang H, Hu X, Zhang X, Zhang Q, Jiang H, Shi W*, Yu H*. Effects of HO-/MeO-PBDEs on androgen receptor: In vitro investigation and helix 12-involved MD simulation, Environmental Science & Technology, 47 (2): 11802–11809 2013
(17) Shi W, Hu G, Chen S, Wei S, Cai X, Chen B, Feng J, Hu X, Wang X, Yu H*. Occurrence of estrogenic activities in second-grade surface water and ground water in the Yangtze River Delta, China, Environmental Pollution, 181: 31-37 2013
(18) Shi W, Wei S, Hu X, Hu G, Chen C, Wang X, Giesy J P, Yu H*. Identification of thyroid receptor ant/agonists in water sources using mass balance analysis and Monte Carlo simulation, Plos One, 8 (10): e73883 2013
(19) Hu X, Shi W*, Zhang Fn, Cao F, Hu G, Hao Y, Wei S, Wang X, Yu H*. In vitro assessment of thyroid hormone disrupting activities in drinking water sources along the Yangtze River. Environmental Pollution, 173: 210-215 2013
(20) Hu X, Shi W*, Cao F, Hu G, Hao Y, Wei S, Wang X, Yu H*. Bioanalytical and instrumental analysis of estrogenic activities in drinking water sources from Yangtze River Delta. Chemosphere, 90(7): 2123-2128 2013
(21) Li X, Ye L, Wang X, Shi W*, Liu H, Qian X, Zhu Y, Yu H*. In silico investigations of anti-androgen activity of polychlorinated biphenyls. Chemosphere, 92(7): 795-802 2013
(22) Li X, Ye L, Shi W*, Liu H, Liu C, Qian X, Zhu Y, Yu H*. In Silico study on hydroxylated polychlorinated biphenyls as androgen receptor antagonists. Ecotoxicology and Environmental Safety, 92(1): 258-264 2013
(23) Cao F, Li X, Ye L, Xie Y, Wang X, Shi W*, Qian X, Zhu Y, Yu H*. Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on the aryl hydrocarbon receptor agonistic activity of hydroxylated polychlorinated biphenyls. Environmental Toxicology and Pharmacology, 36(2):626–635 2013
(24) Li X, Ye L, Wang X, Shi W*, Qian X, Zhu Y, Yu H*. Molecular modeling and molecular dynamics simulation studies on the interactions of hydroxylated polychlorinated biphenyls with estrogen receptor-β, Archives of Environmental Contamination and Toxicology, 65(3): 357-367 2013
(25) Yu N, Shi W, Zhang B, Su G, Feng J, Zhang X, Wei S*, Yu H*. Occurrence of perfluoroalkyl acids including perfluorooctane sulfonate isomers in Huai River basin and Taihu Lake in Jiangsu province, China, Environmental Science & Technology, 47 (2): 710-717 2013
(26) Wang X, Li X, Shi W, Wei S*, Giesy J P, Yu H*, Wang Y. Docking and CoMSIA studies on steroids and non-steroidal chemicals as androgen receptor ligands. Ecotoxicology and Environmental Safety, 89:143-149 2013
(27) Li X. Wang X, Shi W, Liu H. Yu H*. Analysis of Ah receptor binding affinities of polybrominated diphenyl ethers via in silico molecular docking and 3D-QSAR, SAR and QSAR in Environmental Research, 24(1) 75–87 2013
(28) Shi W, Hu X, Zhang F, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Giesy J, Yu H*. Occurrence of thyroid hormone activities in drinking water from eastern China: Contributions of phthalate esters, Environmental Science & Technology, 46 (3): 1811-1818 2012
(29) Shi W, Zhang F, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Giesy J P, Yu H*. Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environment International, 42:117-123 2012
(30) Zheng XM, Liu HL*, Shi W, Wei S, Giesy JP, Yu HX*. Effects of perfluorinated compounds on development of zebrafish embryos. Environmental Science and Pollution Research, 19(7):2498–2505 2012
(31) 王玉婷,于红霞,张效伟,史薇.基于毒性效应的间隙水致毒物质鉴别金属进展.生态毒性学报.11(3):11-25 2016
(32) 邓东阳,于红霞,张效伟,史薇.基于毒性效应的非目标化学品鉴别技术进展.生态毒理学报.10(2):13-25 2015
(33) 郭婧,史薇,于红霞,邓东阳,王玉婷.以毒性效应为先导的有毒物质鉴别研究,南京大学学报.自然科学版. 50(4):414-424 2014 )
 
专利及软件:
(1) 史薇,郭婧,于红霞,Effect-oriented identification of targeted or non-targeted androgen disruptors. 2016.09.11, 美国, ZL 15/261985
(2) 于红霞,史薇,陈钦畅,王小享. Screen methods for thyroid hormone disruptors based on co-regulator involved simulations. 2016.07.07 美国. ZL 15203877
(3) 史薇,邓东阳,于红霞,王玉婷. 一种以大型溞毒性为先导的农药废水中关键致毒物质鉴别方法,2016.04.13.中国, ZL 201410236171.4已授权。
(4) 于红霞,史薇,陈钦畅,王小享. 基于核受体共调节因子的甲状腺激素干扰物虚拟筛选及其干扰活性的定量计算方法. 2016.04.01.中国. 201610201950。
(5) 史薇,郭婧,于红霞. 以效应为导向的目标/非目标雄激素干扰物鉴别方法.2016.04.21.中国.2016102523544。
(6) 于红霞,史薇,王小享.基于分子动力学模拟的核受体介导内分泌干扰物质的虚拟筛选方法,2016.07.20. 中国,ZL 201310288617.3已授权。
(7) 史薇,于红霞,王小享,胡欣欣,王玉婷. 水样中关键拟/抗雄激素干扰毒物快速鉴别方法,2015.01.04,中国,ZL 201310539205.2已授权。
(8) 史薇,邓东阳,于红霞,王玉婷. 三唑类杀菌剂废水中致毒手性单体的识别方法,2015.11.02.中国, 2015107337881.公开。
(9) 于红霞,史薇,曹福,苏冠勇,韦斯. 环境介质有机提取物同步纯化并逐级分离的方法,2012.10.10,中国,ZL 200910232273.8已授权。

交流合作

(1)团队有广泛的国际合作交流,分别与美国、加拿大、德国、日本、芬兰、香港等国家和地区的顶级环境科学研究机构开展实质性的科研合作与人员交流,取得丰硕成果。
(2) We would like to help academic researchers to predict the effective targets of studied compounds for free. System for Predicting Potential Effective Targets (SPET) is used to predict the endocrine systems-involved targets which can be activated by compounds, and the results can be further utilized to evaluate the healthy risk of these compounds. 91 targets related to endocrine systems (nuclear receptors, enzymes involved steroidogenesis, HPA/T/G Axis related proteins and other important targets) are adopted in this software. Research can send the structure of compounds (in the form of mol2 file or PDB file) to this email: njushiwei@nju.edu.cn, and we will give the results back. In principle, we can only perform prediction on 5 compounds per month for each user. (Reference:Wang X, Zhang X, Xia P, et al. A High-throughput, Computational System to Predict if Environmental Contaminants Can Bind to Human Nuclear Receptors [J]. Science of The Total Environment, 2017, 576: 609-616.)



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